This section presents the research and training protocols in which I participated as Principal Investigator or Deputy Investigator, as well as Responsible for Protocol Implementation and Execution. The protocols involve experimental and preclinical models across a wide range of biomedical fields, including regenerative medicine, cardiovascular research, immunology, oncology, vascular surgery, and transplantation research.
My role included the design and implementation of experimental procedures, surgical execution, training of medical and veterinary personnel, and ensuring full compliance with ethical and regulatory requirements. All protocols were approved by the relevant institutional authorities and involved both small and large animal models, aiming to translate basic research findings into clinically applicable practices.
Selected Projects
• Stem cell–based tissue regeneration and repair
Use of mesenchymal stem cells in musculoskeletal and cardiovascular injury models (mice, rats, rabbits).
• Experimental models of cardiovascular disease and atherosclerosis
Investigation of molecular mechanisms, inflammatory responses and angiogenesis in genetically modified animal models.
• Medical device evaluation and interventional techniques
Assessment of cardiovascular and vascular devices in large animal models (pigs).
• Ischemia–reperfusion injury and organ conditioning
Experimental protocols focusing on cardiac and renal protection strategies.
• Immunology and inflammation in sepsis models
Study of Toll-like receptors, PD-1/PD-L1 pathways and cytokine expression in experimental sepsis.
• Tissue engineering and biomaterials
Development and evaluation of scaffolds derived from human umbilical cord and trachea for regenerative applications.
• Educational and training protocols
Hands-on training of physicians and veterinarians in surgical techniques, ultrasonography and robotic surgery.
See the full list
1. Protocol No.: 366893 / 19-05-2021
Use of synovium-derived stem cells for the repair of chronic supraspinatus tendon tears using fascia lata allografts.
(Rabbits, n=12)
2. Protocol No.: 794197 / 24-09-2021
Development and progression of atherosclerosis in ApoE mice under the influence of physical activity combined with inhalation of atmospheric particulate matter.
(Mice, n=76)
3. Protocol No.: 957119 / 11-11-2021
Effect of cilostazol on IL-17 expression in a model of peripheral ischemia in transgenic mice.
(Mice, n=82)
4. Protocol No.: 1314 / 13-03-2019
Experimental model investigating the effect of Platelet-Rich Plasma (PRP) on the healing of standardized partial-thickness burns on the dorsal surface of male rats.
(Sprague-Dawley rats, n=20)
5. Protocol No.: 335435 / 01-07-2019
Training in the use of intraoperative ultrasound in parenchymal organs and management of malignant tumors using energy-based techniques (RF/MW).
(Pigs, n=4)
6. Protocol No.: 1201 / 19-03-2018
Device study in the right and left pulmonary artery.
(Pigs, n=8)
7. Protocol No.: 2744 / 05-06-2018
Effect of IL-28A on ischemia–reperfusion injury following myocardial infarction.
(Mice, n=80)
8. Protocol No.: 1204 / 13-03-2018
Study of renal parenchymal alterations in a model of renal fibrosis induced by unilateral ureteral obstruction.
(Mice, n=22)
9. Protocol No.: 5046 / 22-09-2017
Evaluation of arterial occlusion capability using a novel innovative device.
(Pigs, n=3)
10. Protocol No.: 1755 / 24-03-2017
Histological and quantitative assessment of TLR2, TLR2/1, and TLR2/6 in liver regeneration following 2/3 hepatectomy.
(Mice, n=60)
11. Protocol No.: 5044 / 22-09-2017
Study of the effect of TLRs and PD-1 activation on the intensity and effectiveness of the immune response in an experimental model of intra-abdominal sepsis.
(Mice, n=60)
12. Protocol No.: 5046 / 22-09-2017
Evaluation of arterial occlusion using a novel innovative device.
(Pigs, n=3)
13. Protocol No.: 7922 / 14-12-2017
Study of Achilles tendon rupture repair using mesenchymal stem cells and specialized biomaterials.
(Rats, n=48)
14. Protocol No.: 7918 / 14-12-2016
Study of intracellular EGFR trafficking in colorectal cancer.
(Mice, n=108)
15. Protocol No.: 5880 / 15-09-2016
Study of the progression of aortic valve stenosis using molecular nuclear imaging techniques and microRNA analysis in an experimental rabbit model.
(Rabbits, n=39)
16. Protocol No.: 2772 / 28-04-2016
Transplantation of viable grafts composed of cardiovascular progenitor cells for regeneration of left ventricular cardiomyocytes following experimentally induced acute myocardial infarction.
(Mice, n=42)
17. Protocol No.: 2774 / 28-04-2016
Induction of pyometra in mice for the evaluation of Toll-like receptor function.
(Mice, n=255)
18. Protocol No.: 7924 / 14-12-2016
Immunotherapy in the treatment of pancreatic cancer.
(Mice, n=180)
19. Protocol No.: 2775 / 26-04-2016
Study of renal fibrosis using NR5A2 inhibitors.
(Mice, n=40)
20. Protocol No.: 777 / 28-04-2016
Development of a scaffold derived from human umbilical cord for the repair of peripheral nervous system dysfunctions.
(Rats, n=36)
21. Protocol No.: 2771 / 28-04-2016
Assessment of cardiac ejection fraction in healthy and diseased mice using positron emission imaging and comparison with other imaging modalities.
(Mice, n=92)
22. Protocol No.: 967 / 02-03-2016
Training of veterinarians in ultrasonography techniques.
(Pigs, n=4)
23. Protocol No.: 5879 / 15-09-2016
Training in suturing techniques for enterotomy, enteroanastomosis, and splenectomy.
(Pigs, n=4)
24. Protocol No.: 1152 / 05-05-2015
Production of tracheal scaffolds for the treatment of severe respiratory tract diseases.
(Rats, n=40)
25. Protocol No.: 6654 / 17-12-2015
Development of viable synthetic grafts for anterior cruciate ligament repair.
(Pigs, n=8)
26. Protocol No.: 585 / 02-02-2015
Comparative study of three surgical techniques for repair of experimental diaphragmatic defects, evaluating healing and mobility.
(Rats, n=46)
27. Protocol No.: 585 / 05-02-2015
Comparative study of three surgical techniques for repair of experimental diaphragmatic defects, assessing healing and diaphragmatic muscle mobility.
(Rats, n=32)
28. Protocol No.: 1156 / 12-05-2015
Training in ovariohysterectomy and castration in rabbits.
(Rabbit, n=1)
29. Protocol No.: 3277 / 28-07-2015
Effect of endovascular aneurysm repair on the mechanical properties and histological structure of the aortic wall – pilot study.
(Pigs, n=4)
30. Protocol No.: 5959 / 26-11-2015
Development of vascular grafts from human umbilical cord and assessment of their functionality before and after cryopreservation.
(Pigs, n=5)
31. Protocol No.: 2699 / 26-04-2013
Effect of the antiplatelet agent clopidogrel in transplanted rats.
32. Protocol No.: 4850 / 31-07-2012
Histological and quantitative assessment of Toll-like receptors in the intestine and lungs in septic mouse models.
33. Protocol No.: 648 / 30-01-2012
Evaluation of the anticancer activity of novel embolic agents or substances in animal cancer models using xenografts. Pharmacokinetic study in rabbits following chemoembolization with the investigated microcapsules.
34. Protocol No.: 3955 / 13-06-2012
Pharmacokinetic and toxicological study in rodents following intravenous, intraperitoneal, or subcutaneous administration of nanospheres/drug carriers.
35. Protocol No.: 7047 / 10-12-2012
Allogeneic abdominal aorta transplantation protocol in rats following decellularization and recellularization.
36. Protocol No.: 6221 / 30-10-2012
Application of remote ischemic postconditioning for the inhibition of post-infarction cardiac remodeling following experimental myocardial infarction.
37. Protocol No.: 4854 / 07-08-2012
Histological and quantitative assessment of Toll-like receptors in the intestine and kidneys in septic mouse models – experimental study.
38. Protocol No.: K/2129 / 04-05-2011
Training seminar for surgeons in the use of the Da Vinci robotic surgical system.
39. Protocol No.: 3632 / 26-09-2011
Training in anesthesia techniques for small rodents.
40. Protocol No.: 2573 / 09-06-2011
Role of erythropoietin in the inhibition of cardiac remodeling following acute myocardial infarction.
41. Protocol No.: K/1420 / 13-05-2011
In vivo study of tissue bioavailability, distribution, and antineoplastic activity of fluorescent chromanol esters in an orthotopic colorectal cancer model.
42. Protocol No.: K/6927 / 06-12-2010
Effect of hepatic pedicle clamping combined with colectomy and anastomosis on intrathoracic organs.
43. Protocol No.: K/8591 / 07-04-2010
Study of the effect of the Habib catheter on stabilization of atherosclerotic plaque.
44. Protocol No.: K/6818 / 15-09-2009
Study of the effects of environmental enrichment on recovery quality in rats.
45. Protocol No.: K/3119 / 15-05-2009
Effect of exercise on diabetes – experimental study in rats.
46. Protocol No.: K/6654 / 11-09-2007
Study of the anti-atherogenic effect of rimonabant in combination with exercise.
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